Abiotic house and combining them to build

Abiotic synthesis means making compounds using non-living molecules. It’s possible that organic molecules formed before life began and built up to make the first cells. Let’s explore this theory and its hallmark experiment.

Making Something from Nothing

Imagine a factory that makes conveyor belts.

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These conveyor belts, coincidentally, have to be shipped down conveyor belts as they’re being produced and packaged. Where did the original conveyor belts come from? Could the factory have made them without its own machines to move them around? The conveyor belts in the factory probably would have had to come from someplace else, such as another factory.Cells are a lot like microscopic factories, making proteins, carbohydrates, fats, and nucleic acids. When a new cell is made, it gets its starting materials from the parent cell, just like how our factory needed conveyor belts from another, older factory. But what about the first cells? How did they get all the materials they needed to be cells?

Abiotic Synthesis

Cells contain a lot of organic molecules, which are carbon-based compounds that help do things for the cells. Fats and carbohydrates can store energy, for example, while proteins help reactions happen, and nucleic acids hold the cell’s information. These components are made by cells and make up cells.

Before cells evolved, however, organic molecules would’ve had to have been made via abiotic synthesis.’Abiotic‘ means without life, and ‘synthesis‘ means to make. Abiotic synthesis is, therefore, making things without life. The atmosphere on the early earth most likely contained water vapor, methane gas, ammonia, and carbon dioxide.

These gases contain the major elements found in organic molecules: carbon, oxygen, nitrogen, and hydrogen. Scientists hypothesized that these gases could join up together to make organic molecules, just like taking Lego blocks from a small house and combining them to build a bigger, more elaborate house.If these building blocks of life could be made without cells, then it’s possible that they combined together to eventually form larger molecules. Amino acids could join together to form proteins. Nucleic acids could join together to form small genes, or pieces of information that could be passed on. As these organic molecules became more complex over millions of years, the very first cells could have been formed.

This would be like all of the pieces of the factory coming together to make the final product.

Miller-Urey Experiment

Like any good scientists, two men named Stanley Miller and Harold Urey decided to test the hypothesis that organic molecules could be formed without cells on the early earth. They set up an apparatus and pumped in the gases found in Earth’s atmosphere billions of years ago. They then sent a spark through the gases, to mimic lightning. When the Miller-Urey experiment was completed, the scientists found many organic molecules in the apparatus, including amino acids and nucleic acids, that had formed from the non-living gases and the spark.While this experiment showed that abiotic synthesis of organic molecules is possible, it isn’t definitive proof that this was how life evolved. Still, along with many other experiments, it provides evidence that might someday help explain where life came from.

Lesson Summary

The origin of life on Earth is still an unanswered question. One hypothesis, based on the notion of abiotic synthesis, or the process of making things without life, suggests that small organic molecules, like the amino acids that build proteins, were formed before life existed. These small molecules joined together, becoming more and more complex, until the first cells were formed. The Miller-Urey experiment, which found that organic molecules (including amino and nucleic acids) could be produced from non-living materials, provides some evidence to support this hypothesis.


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