This when hGH is released in excess

This lesson will cover some of the pathologies that are associated with the anterior and posterior pituitary glands.

We will look at the signs and symptoms of each condition. Then test your knowledge with a short quiz.

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Studying Pituitary Pathology

Being a parent has been an exciting experience. There’s nothing like watching your child grow and develop. You have been marking the wall, charting the height of your children.

One day you happen to notice that one of your sons is growing at a faster rate than the others and is quite a bit taller. You think this is great, but want to get him checked out by his doctor to be sure nothing is wrong.Your son’s doctor refers you to a endocrinologist, which is a specialist who studies the hormones and glands of the body.

There are times when something may go wrong with our glands just like with any other part of the body. The diseases and condition of the glands and hormones are called endocrinopathy. There are two main things that may happen when a gland malfunctions. When a gland is overactive, it can cause hypercrinism, a condition due to excessive secretion of hormones. The opposite may happen where a gland is underactive and causes a condition due to not enough secretion of hormones called hypocrinism.

The pituitary gland is responsible for secreting many hormones between the anterior and posterior pituitary. The endocrinologist may check to see if your son is experiencing faster than normal growth due to problems in the pituitary gland since its hormones are responsible for growth. Let’s look at one possibility as well as other pathologies that can arise with the pituitary gland.

Pathologies Related to Hyperpituitarism

Any time the pituitary gland produces and releases more hormones than normal, this is known as hyperpituitarism. Hyperpituitarism is likely due to pituitary adenoma, which is a tumor in the pituitary gland that is non-cancerous. The tumor may appear anywhere in the anterior or posterior pituitary gland.

Where the tumor is located will determine which hormones are released in excess. hGH, or human growth hormone, may be the hormone released in excess with this condition. The timing of when hGH is released in excess is also important in determining which condition could be occurring.Since your son is young and hasn’t reached puberty, the most likely condition would be gigantism. This is when excessive hGH is released before puberty causing bones to grow longer. Some of the signs and symptoms that you may notice if your son has this condition are that he is growing taller quickly and has a larger body size than other children his age. Over time, you may realize that sexual and mental growth is actually happening slower than other children his age.

The other condition that it could have been, if he was older, that falls under hyperpituitarism is acromegaly, which occurs when hGH is released in excess after puberty is complete. hGH released at this point will cause the bones of the face and soft tissues to grow as opposed to the bones of the arms and legs. Some signs and symptoms of this condition are larger hands and feet, jaw growth causing the teeth to separate and joint pain. This is most often seen in adults around the age of 30 to 40.

Pathologies Related to Hypopituitarism

Just like your son may have too much activity, there can also be a lack of activity in the pituitary gland. Hypopituitarism is when the pituitary gland doesn’t release enough or any of its hormones. This condition is most severe if the anterior pituitary hormones are the ones not being released since there are so many of them. Problems with slow growth, metabolism, and sexual development may occur as a result of this condition. The hormones of the pituitary gland are largely responsible for communicating with other glands in the body, so these glands and the hormones also reduce in function.While your son is growing very fast, there are some parents wondering why their son or daughter is growing very slowly. Growth hormone deficiency is a condition of decreased hGH that causes underdevelopment or dwarfism.

Some symptoms of this condition are being extremely short, smaller than other children the same age, mental retardation and lack of development of secondary sex characteristics. The doctor will normally give hGH shots to a child to help with development until the child grows to about 5 feet tall.Prolactin is one of the hormones produced by the anterior pituitary gland. Prolactinoma is a tumor in the anterior pituitary gland causing the excessive release of prolactin. The excessive release of prolactin results in decreased levels of the sex hormones estrogen and testosterone, which is why it is considered to be hypopituitarism. Prolactin normally causes breast development and milk production after having a baby. The signs and symptoms that may happen when it is released in excess include headaches, infertility, problems with vision and loss of sex drive.

This condition also has signs and symptoms that differ based on your sex. Males with prolactinoma may develop breasts and experience erectile dysfunction, while females may have missed periods, vaginal dryness, and a milk-like discharge from their breasts.One of the last conditions that may result due to problems with the pituitary gland occurs in the posterior pituitary. ADH (antidiuretic hormone), or vasopressin, is released by the posterior pituitary to communicate with the kidneys to help maintain water and electrolyte balance in the blood. If vasopressin is not released or a decreased amount from what is needed is released, then diabetes insipidus, or DI for short, might occur. This is a condition in which an imbalance in water metabolism causes the body to release very dilute and colorless urine. Some signs and symptoms of DI include excessive thirst, dehydration, excessive urination, hypotension, and dizziness.

Lesson Summary

We have covered pathology of the pituitary gland in this lesson. You now know that an endocrinologist is a person who studies the glands and hormones. Endocrinopathy are the diseases and conditions of the glands and hormones.

We learned that hypercrinism is when conditions are caused by excess secretion of hormones, while hypocrinism is when conditions are caused by decreased or loss of secretion of hormones.Hyperpituitarism is when the pituitary gland releases excess amounts of pituitary hormones. We know that it is normally caused by pituitary adenoma, which is a tumor in the pituitary gland.

Excessive release of hGH before puberty causes gigantism, but excessive release of hGH after puberty causes acromegaly. The condition of absent or decreased hGH causing underdevelopment or dwarfism is growth hormone deficiency.The other conditions that we covered that are not related to hGH specifically are hypopituitarism, which is decreased or missing release of pituitary hormones, prolactinoma, which is a tumor in the anterior pituitary gland that causes release of extra prolactin, and diabetes insipidus, which is a water metabolism imbalance due to lack of ADH release.

What does the pituitary gland do?

Pituitary Gland

When working correctly, the pituitary gland regulates our body’s growth and development. However, when it is not working correctly, we are faced with conditions such as gigantism, dwarfism, and even mental retardation.

While the pituitary gland may be small, it is an important part in our development.

Learning Outcomes

After reviewing this lesson, you should be able to:

  • Define pituitary pathology and relevant terminology
  • Describe what an endocrinologist is and what they do
  • Identify the differences between hyperpituitarism and hypopituitarism

Medical Disclaimer: The information on this site is for your information only and is not a substitute for professional medical advice.


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