Tramadol is a prescription medication used to treat pain. In this lesson, we will learn how Tramadol relieves pain as well as how the body processes the medication.
Jeanie is an 83-year-old woman who lives alone. Last week, she stepped off her doorstep and fell down. She had a lot of pain in her ankle and her daughter took her to see her doctor. The doctor ordered an x-ray and verified that her ankle wasn’t broken. He encouraged Jeanie to elevate the ankle and apply ice. He also gave her a prescription for Tramadol to help with the pain.
Tramadol is a medication often prescribed for moderate to severe pain. It is available by prescription only. It is used as needed for pain control as directed by a doctor and is also available in a long-acting form to manage chronic pain.
Let’s look deeper into the pharmacology of Tramadol.
Mechanism of Action
Mechanism of action refers to how the body works on a cellular level to produce the intended effects of a drug. In the case of Tramadol, the intended effect is pain relief.
The mechanism of action for Tramadol is not exactly known. But it is known to act on the mu opioid receptors to produce pain relief. Opioid receptors are located in the brain and there are three types, of which the mu opioid receptor is one.
Normally, when a painful stimulus occurs, a neuron communicates to the brain and the person feels pain. When a person takes Tramadol, it acts on the mu opioid receptor, blocking the neuron from communicating pain to the brain.Picture it this way: you have a dragon, a knight with a shield, and a princess. The dragon represents pain, the knight represents the neuron, and the shield represents Tramadol. The princess represents the brain. The dragon breathes fire on the princess! But the knight grabs his shield and blocks the fire from reaching the princess! In the same way, Tramadol acts to block the painful sensation from reaching the brain.
And the knight and princess live happily ever after!So, let’s now look at how the body processes Tramadol.
Pharmacokinetics includes absorption, metabolism, and elimination of a drug. Simply put, it is how the body processes a medication. Absorption is how the body absorbs a drug.
Tramadol is rapidly absorbed after oral administration and quickly distributed throughout the body. After Tramadol is ingested, it attaches to plasma proteins in the blood and is then carried throughout the body.Metabolism involves a wide variety of processes that occur in the body to either build up a substance or break it down. Tramadol is metabolized in the liver into an active metabolite.
The active metabolite is the active form of the drug. Compare it to the Hulk. The Hulk is just a normal man until he gets angry and turns into the Hulk! The anger turns him into a powerful being, just like the liver transforms Tramadol into an active metabolite that will be powerful enough to stop the pain!Elimination is how a drug gets out of the body, and Tramadol leaves the body in urine. Half-life is how long it takes for half of the drug to get out of your system. The half-life of Tramadol is six to eight hours; however, the half-life of the active metabolite is slightly longer at seven to nine hours.
Tramadol is a medication used to treat moderate to severe pain.
The mechanism of action is not clearly understood, but it is known that Tramadol acts on the mu receptors in the brain to stop pain.Pharmacokinetics involves absorption, metabolism, and elimination of a drug. Tramadol is absorbed after taking the drug orally and is distributed throughout the body.
It is metabolized by the liver into an active metabolite. The half-life of tramadol is six to eight hours and seven to nine hours for the active metabolite. Tramadol is excreted from the body in urine.Medical Disclaimer: The information on this site is for your information only and is not a substitute for professional medical advice.